The final in May went to penalties which Unai Emery’s side eventually won 11-10. Not only will Ole Gunnar Solskjaer want vindication for that result but he needs a victory after United lost their league opener to Young Boys.
He said: “We need 12 points to go through. You need to win your home games, win one away from home and go through. A missed opportunity, of course, but then again last year we won our first two games against PSG and Red Bull [Leipzig] and everyone thought we were through. So we have five games to get the 10 or 12 points.”
Here’s all you need to know about the match.
When is it?
The match will kick off at 8pm on Wednesday, 29 September at Old Trafford.
Where can I watch?
The fixture will be available to watch on BT Sport 3 with coverage starting at 7.15pm. Subscribers will also be able to stream the game on the app and website.
For United, Marcus Rashford and Amad Diallo remain out through injury. Harry Maguire is out while Luke Shaw took a knock in their defeat to Aston Villa. Aaron Wan-Bissaka is suspended.
For Villarreal, Gerard Moreno remains injured and Dani Raba, Samuel Chukwueze and Juan Foyth are in doubt for the fixture. Francis Coquelin will also not feature as he is suspended.
United: De Gea, Dalot, Varane, Lindelof, Telles, Fred, McTominay, Pogba, Fernandes, Greenwood, Ronaldo
Villarreal: Rulli; Estupinan, Torres, Albiol, Pedraza; Pino, Capoue, Parejo, Trigueros; Dia, Alcacer
United – 4/9
Draw – 17/5
Villarreal – 11/2
Solskjaer won’t make the same mistake twice against Villarreal and United will be dogged after losing their opener to Young Boys. The Spanish side will present a challenge but United will come out on top. United 1-0 Villarreal.