United are chasing another victory after Cristiano Ronaldo’s last-gasp heroics in their previous European match against Villarreal.
Atalanta meanwhile are top with four points, and will prove stiff opposition.
Here is everything you need to know.
When is the match?
Manchester United vs Atalanta is tonight, Wednesday 19 October, at 8pm BST.
How can I watch it?
The game will be shown live in the UK on BT Sport. Subscribers can stream online via the BT Sport app and BT Sport website.
What is the team news?
Manchester United will be without the injured Raphael Varane and Anthony Martial, while Aaron Wan-Bissaka returns from suspension. Atalanta are without injured wingbacks Hans Hateboer and Robin Gosens.
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Pogba, Fernandes, Greenwood; Ronaldo.
Atalanta: Musso; Palomino, Demiral, Toloi; Zappacosta, Freuler, De Roon, Maehle; Malinovskyi, Ilicic, Zapata.
Man United 3/4
United desperately need a victory to lift morale after a hammering at Leicester on the weekend, and have the firepower to get one here. Manchester United 2-0 Atalanta.