The Foxes saw off their Russian rivals last time out thanks to an incredible four-goal haul from Patson Daka.
It leaves them third in Group C but securing a second successive win would put them into the top regardless of the score from the group’s other fixture on the night.
Here’s everything you need to know ahead of the game.
When is the match?
The game kicks off at 8pm on Thursday 4 November at the King Power Stadium.
Where can I watch it?
The match will be broadcast live on BT Sport 1 and BT Sport Ultimate. Subscribers can stream the match via the BT Sport app and desktop website.
What is the team news?
The Foxes remain without long-term absentees Wilf Ndidi, James Justin, Wes Fofana and Marc Albrighton. Ricardo Pereira should be back after a knock.
Spartak are without Ezequiel Ponce, Nail Umyarov and Pavel Maslov. George Melkadze is also a doubt.
LEI – Schmeichel; Amartey, Vestergaard, Soyuncu; Castagne, Tielemans, Choudhury, Bertrand; Lookman, Daka, Barnes
SKM – Maksimenko; Caufriez, Gigot, Dzhikiya; Moses, Litvinov, Zobnin, Lucas; Promes, Larsson, Sobolev
Leicester won away and should do the same at home, boosting their chances of European action into the new year. Leicester 2-0 Spartak.