The sides are sixth and seventh in the table ahead of the weekend but either team suffering defeat could leave them mid-table by the end of the matchweek.
Here’s everything you need to know ahead of the game.
When is the match?
The game will kick off at 5:30pm on Saturday 30 October at the Tottenham Hotspur Stadium.
Where can I watch it?
The match will be shown live on Sky Sports Premier League, Sky Sports Main Event and Ultra HD. Subscribers can stream the match via the Sky Go app. If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription. We may earn commission from some of the links in this article, but we never allow this to influence our content.
What is the team news?
Spurs are still without Ryan Sessegnon, but Bryan Gil is the only other doubt.
United have many more absences, starting with Paul Pogba who is suspended after his red card against Liverpool. Anthony Martial is back from a long lay-off but faces a fight for a place, while Raphael Varane may be hurried back into the XI after a shambolic defensive showing last weekend.
TOT – Lloris; Tanganga, Romero, Dier, Reguilon; Skipp, Hojbjerg, Ndombele; Moura, Kane, Son
MNU – De Gea; Wan-Bissaka, Varane, Maguire, Shaw; McTominay, Matic; Lingard, Fernandes, Rashford; Ronaldo
Man United 17/12
Tottenham won’t fear United and will give them problems, but surely Solskjaer’s side have to come together to produce a vastly improved showing under pressure. Spurs 2-2 Man United.