Ole Gunnar Solskjaer’s side required a late winner from Cristiano Ronaldo to snatch victory against Villarreal in the Champions League on Wednesday night.
Before that game, Solskjaer’s side had been beaten twice at home in quick succession against West Ham and Aston Villa.
Everton have begun the season well under Rafa Benitez and would go ahead of their opponents with victory.
Indeed, either side would go top with a win at Old Trafford in the first game of the weekend.
Here’s everything you need to know before the Premier League fixture.
When is it?
The match will kick off at 12.30pm BST on Saturday 3 October at Old Trafford.
Where can I watch?
The fixture will be available to watch on BT Sport 1, with coverage beginning at 11.30am BST.
BT Sport subscribers can stream the game on the broadcaster’s website and app.
The fitness of two defenders may necessitate two alterations for Ole Gunnar Solskjaer. Maguire has been ruled out for several weeks after suffering a calf injury, while Luke Shaw missed their midweek action after going off against Aston Villa.
Shaw may be fit to retake his place at left-back, with Victor Lindelof likely to again partner Raphael Varane in the heart of the defence. Marcus Rashford is expected to return from his injury lay-off after the international break.
Everton are likely to continue to be without both Seamus Coleman and Dominic Calvert-Lewin, though the pair returned to individual training this week. Richarlison remains absent, while Andre Gomes also did not train after missing last weekend’s win over Norwich.
Midfielder Jean-Philippe Gbamin has had a torrid time with injury since his arrival on Merseyside in 2019 but is moving closer to a return.
Man United XI: De Gea, Wan-Bissaka, Varane, Lindelöf, Shaw, McTominay, Fred, Bruno Fernandes (c), Martial, Greenwood, Cavani
Subs: Sancho, Cristiano Ronaldo, Lingard, Matic, Pogba, Henderson, Telles, van de Beek, Bailly
Everton XI: Pickford, Godfrey, Mina, Keane, Digne (c), Doucouré, Allan, Townsend, Gordon, Rondón, Gray
Subs: Braithwaite, Gbamin, Holgate, Davies, Whitaker, Lonergan, Dobbin, Kenny, Begovic
Manchester United – 9/20
Draw – 10/3
Everton – 13/2
Manchester United will be desperate to avoid another disappointing performance at home, but Benitez’s Everton appear to be settling well. However, short of a few key individuals, they may just lose out in a tight encounter. Manchester United 2-1 Everton.