Mikel Arteta’s side have begun to string together a couple of good results after surviving a trip to Burnley on Saturday.
With a fixture against Tottenham this weekend looming, Arteta may look to rotate.
Mark Robinson’s Wimbledon are seventh in League One and will look to trouble their Premier League opposition – they have already scored 15 league goals this season.
Here’s all the information you need before the fixture.
When is it?
The match will kick off at 7:45pm BST on Wednesday 22 September at the Emirates Stadium.
How can I watch?
The game will not be shown live on television in the United Kingdom, though highlights can be seen on Quest from 10.30pm BST on Wednesday 22 September.
Arsenal — Leno; Cedric, Holding, Mari, Tavares; Sambi, Thomas; Maitland-Niles, Martinelli, Nketiah; Lacazette
AFC Wimbledon — Tzanev; Lawrence, Nightingale, Heneghan, Guinness-Walker; Hartigan, Woodyard; Rudoni, McCormick, Assal; Palmer
AFC Wimbledon: 28/1
Arsenal beat a callow West Brom 6-0 in the previous round and while a repeat scoreline would be a surprise, Arteta’s side should advance in reasonable comfort. Arsenal 3-1 Wimbledon